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TP13

Code: TP13	Time Slot/Poster Number: 090	Session: Raman Instrumentation
Development of Highly Sensitive Compact Raman Scanner for Mass Screening of Chemical Dyes
Dinish U. S; Chit Yaw Fu; Malini Olivo
Singapore Bioimaging Consortium, 11 Biopolis Way, Singapore

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Summary
In the Raman analysis of various chemicals, it is often required to do mass screening of dyes and their derivatives. In most cases, it is impractical to screen each dye one by one on a commercial Raman system, which is catered to screen one analyte at a time. In this context, we proposed the design of simple, cost effective and compact ‘Raman Scanner’ developed using commercial laser, detector and optical components. The high throughput screening capability of the system is demonstrated by acquiring the SERS spectra of various molecules adsorbed on to gold colloid in a 96 well plate.

Code: TP13	Time Slot/Poster Number: 091	Session: Raman Instrumentation
In-Situ Raman monitoring of UO2/H2O interfaces under He2+ irradiation
Aurélien Canizares¹; Guillaume Guimbretiere¹; Yeny Alexandra Tobon-Correa¹; Nicole Raimboux¹; Michel Perdicakis²; Benoist Muzeau³; Mohammad S. Alam³; Marie-France Barthe¹; Catherine Corbel^{1, 3}; Patrick Simon¹
¹CNRS UPR 3079 CEMHTI, Orleans , France; ²CNRS-Nancy Université LCPME, Nancy, France; ³CNRS-CEA-Ecole Polytechnique LSI, Palaiseau, France

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Summary
An in-situ Raman device is developed to monitor the behavior of UO2/H2O solid/liquid interfaces, during irradiation by a He2+ beam supplied by a cyclotron. This allows access to the alteration mechanisms of the solid, through decomposition of water under alpha-radioactivity and the appearance of stable and transient reactive radiolytic species. The progressive appearance of oxidized U(VI) alteration phases phases is evidenced. These experiments intend to give a better knowledge of nuclear spent fuel behavior in case of contact with water in underground storage. Besides, this in-situ Raman device can be applied to any other material under irradiation.

Code: TP13	Time Slot/Poster Number: 092	Session: Raman Instrumentation
Quantitative Stand-off Raman Scattering
Bernhard Zachhuber¹; Maria C. Alcudia-Leon^{1, 2}; Bernhard Lendl¹
¹Vienna University of Technologie, Vienna, Austria; ²University of Cordoba, Cordoba, Spain

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Summary
Here we present a multivariate analysis of stand-off Raman spectra of xylene isomer mixtures as an example of how techniques, more commonly applied to conventional Raman spectroscopy, can also be applied to stand-off detection. A multivariate calibration has shown that quantitative analysis of stand-off Raman spectra from liquid, multicomponent mixtures is achievable. The validation of this method indicates that for m- and p-xylene prediction of concentration is accurate to ±0.5%, and ±1.5% for o-xylene. As stand-off Raman spectroscopy improves and finds its way into more routine analyses there will be increasing requirements for quantification of the signals obtained.

Code: TP13	Time Slot/Poster Number: 093	Session: Raman Instrumentation
Combined LIBS & Raman Spectroscopy: Automated High Throughput Particle Identification (>20µm) for Industrial Contamination Analysis & Forensics Investigations.
Oliver Valet
Berlin, Germany

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Summary
The SPE raman.ID + metal.ID 20 uses Raman Spectroscopy to identify the chemical composition and the elemental distribution of particles (from 20 µm) at a throughput rate of 100 - 1000 particles per hour. For the first time two orthogonal spectroscopy technologies can identify unknown particle material. Particle count, shape, and size from 0.5 µm and above can be determined by using a particle size distribution with 8 customizable size classes.

Code: TP13	Time Slot/Poster Number: 095	Session: Raman Instrumentation
Applications of Hyphenated DSC-Raman Spectroscopy to Polymers
Kevin Menard; Jeffery Taylor; David Norman; Enrique Lozano Diz; Richard Spragg
PerkinElmer LAS, Denton, TX

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Summary
The combination of simultaneous DSC and Raman Spectroscopy is applied to polymers to track changes in polymer structure while also tracking the phase changes in the material. A system consisting of a dual furnace DSC and a Raman spectrometer is described and applied to polymers with controlled heating and cooling.

Code: TP13	Time Slot/Poster Number: 096	Session: Raman Instrumentation
Construction of Multichannel Low-Frequency Raman Microspectrometer of Spectral Coverage to 20 cm-1 with Gratings Formed in Glass Plates
Atsuko Tsurumi; Yasuaki Naito; Koichi Iwata
Department of Chemistry, Gakushuin University, Tokyo, Japan

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Summary
We have constructed a multichannel Raman microspectrometer with new Notch filters and examined its performance. A grating is formed inside the glass plate of each Notch filter. We measured the Raman spectrum of L-cyctine that has a number of Raman bands in the low frequency region with our Raman microspectrometer. It is possible to record the low frequency region down to 20 cm-1 with this multichannel Raman microspectrometer.

Code: TP13	Time Slot/Poster Number: 097	Session: Raman Instrumentation
Towards Stand-Off Resonance Raman Spectroscopy
Alison Hobro; Bernhard Zachhuber; Bernhard Lendl
Vienna University of Technology, Vienna, Austria

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Summary
Stand-off Raman is advantageous where samples are dangerous, fragile or difficult to access. Exploiting resonance Raman through careful laser excitation choice, increases the sensitivity of Raman spectroscopy and also means that the spectra obtained are selective for the part of the analyte associated with the chromophore. Therefore, combining these spectroscopies is likely to yield an analysis technique that can be used to probe a sample for specific molecules from a distance. Here we present our work towards stand-off resonance Raman with examples including the detection of carotinoids in leaves.

Code: TP13	Time Slot/Poster Number: 098	Session: Raman Instrumentation
Vibrational Spectroscopic Studies and DFT calculations of 2,6 Diphenyl 4 Piperidone
Sridevi C¹; G Velraj²; R Palanivel³
¹Sona college of Technology, Salem, India; ²Department of Physics, Periyar University, Salem-636011, Tamilnadu, India; ³Department of Physics, Annamalai University, Annamalainagar-608002,Tamilnadu, India

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Summary
In the present investigation, Vibrational spectroscopic studies and DFT calculation have been performed on 2,6 Diphenyl 4 Piperidone. Laser Raman and FTIR spectra were recorded and their tentative vibrational assignments are discussed clearly. The theoretical results obtained from the studies shows good agreement with experimental values. Comparision of the observed fundamental frequencies of 2,6 Diphenyl 4 Piperidone and the results calculated by HF and DFT methods indicate that B3LYP is superior to scaled HF approach for vibrational problems.

Code: TP13	Time Slot/Poster Number: 099	Session: Raman Instrumentation
FT-IR and Laser Raman Spectroscopic Analysis of 4-Amino-3-Bromopyridine
Velraj G¹; R Sudha¹; N Senguttuvan²
¹Periyar University, Salem, India; ²Department of Physics,Kandaswami Kandar’s College, Paramathi Velur, Tamilnadu, India

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Summary
Pyridine derivatives are one of the most used frame works for medicines, food flavorings, dyes, agrochemicals, rubber chemicals, and adhesives in drug discovery. In the present investigation, an attempt have been made to record the FTIR and Laser Raman spectra for 4–amino –3–bromo pyridine and their tentative vibrational assignments are discussed clearly.

Code: TP13	Time Slot/Poster Number: 100	Session: Raman Instrumentation
Brillouin Scattering in Ethanol-Water Mixtures
Augustinus Asenbaum¹; Bernarda Kezic²; Christian Pruner¹; Franjo Sokolic²; Emmerich Wilhelm¹
¹Experimental Physics, University of Salzburg, Salzburg, AUSTRIA; ²Department of Physics, University of Split, Split, CROATIA

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Summary
We present Brillouin scattering measurements on ethanol-water mixtures at 293.15 K. The spectrometer was a 6-pass tandem Fabry-Perot interferometer with a finesse of about 80, FSR = 15.00 GHz. The scattering angle was 90°. Ultrasonic speed measurements at 3 MHz and index of refraction data at 514.5 nm are also reported. Of particular note is the sound dispersion between 0.1 and 0.6 mole fraction ethanol. The structural relaxation times derived from the experimental Brillouin spectra in the region around 0.2 mole fraction are in rough agreement with dielectric relaxation times.

Code: TP13	Time Slot/Poster Number: 101	Session: Raman Instrumentation
Microfluidic Raman Spectroscopy for Bio-analyte Detection
Praveen Ashok; Gajendra Singh; Khay Tan; Kishan Dholakia
University of St. Andrews, St. Andrews, United Kingdom

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Summary
We report a novel fiber probe based Raman detection system on a microfluidic platform where a split Raman probe is directly embedded into a Polydimethylsiloxane (PDMS) chip. The sensitivity of the system is evaluated by quantitative estimation of urea and the system could detect human physiological level of urea. The prospect of a Raman detection system built on PDMS based microfluidic platform makes this technology inexpensive and biocompatible. Unlike conventional bulk optics based Raman detection schemes in microfluidics, our approach will help to develop point of care, environmental microfluidic monitoring, biotechnological and forensic portable detection devices utilizing Raman spectroscopy.

Code: TP13	Time Slot/Poster Number: 102	Session: Raman Instrumentation
On axis Resonance Raman microspectroscopy combined with macromolecular crystallography at the Swiss Light Source
Martin R. Fuchs¹; Guillaume Pompidor¹; Vincent Thominet¹; Robin L. Owen²; Arwen Pearson³; Clemens Schulze-Briese¹
¹Swiss Light Source, Paul Scherrer Institute, Villigen, Switzerland; ²Diamond Light Source, Didcot, United Kingdom; ³University of Leeds, Leeds, United Kingdom

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Summary
Macromolecular crystallography is a powerful method to obtain structural information of biomolecules and molecular assemblies down to atomic resolution. Optical spectroscopic techniques such as UV/Vis absorption, fluorescence and (resonance) Raman spectroscopy can provide valuable complementary information that can not be inferred from the crystal structure alone. A multimode microspectrophotometer for in-crystallo optical spectroscopy has been developed at beamline X10SA of the Swiss Light Source. It can be configured for UV/Vis, fluorescence and Raman spectroscopy. We present selected results obtained with the Raman configuration of the spectrometer and discuss the current instrument design as well as upgrades currently being implemented.

Code: TP13	Time Slot/Poster Number: 103	Session: Raman Instrumentation
Crystalline Colloidal Array Deep UV Narrow Band Radiation Filter
Luling Wang; David Tuschel; Alexander Tikhonov; Sanford Asher
University of Pittsburgh, Pittsburgh, PA

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Summary
We fabricated a deep UV filter by crystalline colloidal array (CCA) technology. We developed a synthesis of monodisperse highly charged small silica particles. These highly charged silica particles self assembled into CCAs in low ionic strength liquid media and Bragg diffracted light in the deep UV range. The CCA filter showed narrow bands and high rejection efficiency at the Bragg diffracted wavelength in the deep UV range. We also demonstrated the high rejection efficiency of the CCA filter for the Rayleigh scattered light at 229 nm while passing adjacent Raman bands.

Code: TP13	Time Slot/Poster Number: 104	Session: Raman Instrumentation
Molecular and vibrational structure of 3-amino-2-bromo pyridine: FT-IR, FT-Raman and Quantum chemical calculations
Velraj G¹; Kandasamy M²
¹Periyar University, Salem, India; ²Arignar Anna Government Art College, Namakkal-636 001,Tamilnadu, India

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Summary
One of the most successful selective scaling schemes, developed with deep understanding of the nature of molecular vibrations, is the so-called Scaled Quantum Mechani¬cal (SQM) force field method. Based on the SQM force field obtained by DFT calculations at B3LYP/6-311+G** levels, complete vibrational properties of ABP32 have been investigated by FT-IR and FT-Raman spectroscopic techniques. The roles of amino and bromine groups in the vibrational frequencies of the title compounds are discussed and their tentative vibrational assignments are explained in detailed.

Code: TP13	Time Slot/Poster Number: 105	Session: Raman Instrumentation
Near-Infrared Raman Spectroscopy Using Hollow-Core Photonic Bandgap Fibers
K. M. Eddie Tan; Gajendra P. Singh; C. S. Herrington; C. T. A. Brown
University of St. Andrews, St. Andrews, United Kingdom

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Summary
We report a NIR Raman spectroscopy system incorporating hollow-core photonic bandgap fibers (HC-PBFs) in both the excitation and collection paths. Raman excitation was achieved at NIR laser wavelength of 785 nm. We demonstrate that using HC-PBFs, Raman spectroscopy can be performed without the use of an additional longpass filter on the collection side. A narrow bandpass filter on the excitation side is also not required. These results provide a framework where HC-PBF based Raman probes can be developed and used in space restricted biomedical and sensing applications.

Code: TP13	Time Slot/Poster Number: 106	Session: Raman Instrumentation
Raman microscopy imaging: improving detection through nonlinear optical interaction
Vladislav Yakovlev
University of Wisconsin - Milwaukee, Milwaukee, WI

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Summary
Raman spectroscopy based on spontaneous scattering cannot compete with nonlinear Raman spectroscopy, when the sample volume is large enough to take advantage of the coherent nature of nonlinear optical interactions. However, when the interaction volume is small, the number of optical photons generated through spontaneous Raman scattering can be larger than the number of photons generated by coherent Raman process. In this work, the signal-to-noise ratio for Raman spectroscopy is carefully evaluated, and, by optically amplifying the weak Raman signal, Raman spectra, free of background noise are achieved.

Code: TP13	Time Slot/Poster Number: 107	Session: Raman Instrumentation
Raman Scattering in a Dimethyl Sulfoxide-Filled Hollow-Core Photonic Crystal Fiber
Anna Chiara Brunetti; Karsten Rottwitt
DTU Fotonik, Kgs. Lyngby, Denmark

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Summary
The Raman spectrum of Dimethyl Sulfoxide (DMSO) infiltrated in a Hollow-Core Photonic Crystal Fiber with a core of 5μm has been measured and compared to the spectrum of DMSO in glass capillary tubes and in a glass cuvette.

Code: TP13	Time Slot/Poster Number: 108	Session: Raman Instrumentation
Combining Atomic Force Microscopy with Polarized Raman Microscopy
Juergen Sawatzki
chemist, Ettlingen, Germany

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Summary
Raman microscopy and atomic force microscopy integrated in an optical microscope provide a comprehensive picture for the study of surfaces and thin films. Topographical information from the AFM can be directly related to molecular spectroscopic information in the Raman spectra.

Code: TP13	Time Slot/Poster Number: 109	Session: Raman Instrumentation
High Performance Resonance Raman Spectroscopy Using Volume Bragg Gratings as Tunable Light Filters
Marc Verhaegen¹; Matthieu Paillet²; François Meunier³; Sébastien Blais-Ouellette¹; Richard Martel²
¹Photon etc, Montreal, Canada; ²Département de Chimie, Université de Montréal, Montréal, Canada; ³Département de Physique, Université de Montréal, Montréal, Canada

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Summary
We designed a near infrared tunable resonance Raman spectroscopy system based on a tandem of thick volume Bragg gratings (VBGs). VBGs are here the constituents of two light filtering units: a tunable laser line filter (LLF) and a tunable notch filter (NF). When adapted in a micro-Raman setup with a single stage monochromator, the tandem of LLF and NF allowed measurements of Raman signals down to 20 cm-1. The good performance and fast tunability of the VGB Raman system was demonstrated on a sulfur powder and on a bulk single-walled carbon nanotube sample.

Code: TP13	Time Slot/Poster Number: 110	Session: Raman Instrumentation
Compact low frequency Raman spectroscopy system
Christophe Moser; Frank Havermeyer
Ondax, Inc / EPFL, Monrovia, CA

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Summary
We have developed a compact low frequency Stokes and anti-Stokes Raman spectroscopy system capable of resolving frequency shifts down to 15 cm-1. The Raman system uses ultra-narrow band notch filters that are fabricated holographically in a glass material. The notch filters have optical densities ranging from 4 to 6 per notch filter at the standard Raman laser lines and greater than 80% transmission at 15 cm-1 away from the laser line. This simple notch filter-based system provides high performance low frequency Raman spectroscopy as a low cost alternative to bulky and expensive triple spectrometer Raman systems.

Code: TP13	Time Slot/Poster Number: 111	Session: Raman Instrumentation
Combined High Resolution AFM and Raman Microanalysis
Thomas Tague¹; David Sampson²
¹Bruker Optics, Billerica, MA; ²Bruker Nano, Madison, Wisconsin

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Summary
Rapid combined AFM and Raman analysis has been performed on nanotubes and daguerrotype photographic plates. The fine featured samples demonstrate the importance of AFM and Raman analysis without having to move the sample.

Code: TP13	Time Slot/Poster Number: 112	Session: Raman Instrumentation
New Directions in AFM-Raman BioImaging in Liquids
Aaron Lewis¹; Anatoly Komisar²; Rimma Dekhter²; David Lewis²
¹Hebrew University of Jerusalem, Jerusalem, Israel; ²Nanonics Imaging Ltd., Jerusalem, Israel

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Summary
A new feedback mechanism for AFM imaging in liquids will be introduced. This new approach is based on tuning fork technology which has been shown to be the most effective method of AFM feedback. Thanks to their high Q factors, tuning forks allow for improving feedback sensitivity and imaging quality. It will be shown how these unique characteristics can now be extended to liquid environments for bioimaging.

Code: TP13	Time Slot/Poster Number: 113	Session: Raman Instrumentation
Very Low Frequency Stokes and Anti-Stokes Raman Spectra Accessible with a Single Multichannel Spectrograph and Volume Bragg Grating Optical Filters
Alexandra Rapaport^{1, 2}; Bernard Roussel^{1, 2}; Hans-Juergen Reich^{1, 2}; Fran Adar^{1, 2}; Alexei Glebov ³; Oleksiy Mokhun³; Vadim Smirnov³; Leonid Glebov³
¹Horiba Scientific, Edison, ; ²HORIBA Scientific, Villeneuve d'Ascq, France; ³OptiGrate Corp, 3267 Progress Dr.,, Orlando, Florida 32826

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Summary
Multichannel measurement of Raman bands with frequencies very close to the excitation line has traditionally been possible with the use of triple monochromator systems. These systems are very flexible, but they can be complex to use, large, low in throughput, and expensive. We have recently demonstrated the use of a single monochromator Raman system where the Rayleigh filtering elements are made of Volume Bragg Gratings (VBGs); such a system enabled recording of Stokes and anti-Stokes modes with frequencies less than 10 cm-1.

Code: TP13	Time Slot/Poster Number: 114	Session: Raman Instrumentation
Development of 1064 nm Excited Multichannel Raman Microspectrometer and Its Application to in vivo Measurements of Cyanobacteria
Masahiro Ando¹; Miwa Sugiura²; Hidenori Hayashi²; Hiro-o Hamaguchi^{1, 3}
¹The University of Tokyo, Tokyo, Japan; ²Ehime University, Matsuyama, Japan; ³National Chiao Tung University, Hsinchu, Taiwan

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Summary
Near-infrared (NIR) excited Raman microspectroscopy is highly useful for in vivo studies of biological samples, which often show strong fluorescence that interfere the Raman measurements. However, some biological samples emit strong fluorescence even with NIR excitation at 800 nm. For the purpose of further overcoming this difficulty, we have developed a 1064 nm deep NIR excited multichannel Raman microspectrometer with the sensitivity high enough for measurements of single living cells. In this presentation, its application to the in vivo Raman measurements of cyanobacteria, which emit strong fluorescence with 800 nm excitation, is also reported.