Code: WOD	Time Slot/Poster Number: 10:30 - 11:00 am	Session: Industrial Applications & Raman Instrumentation
The Application of Raman Spectroscopy for Pharmaceutical Secondary Manufacturing
Ian Lewis1; Kevin Davis1; Sean Gilliam1; Herve Lucas2; Carsten Uerpmann2
1Kaiser Optical Systems, Inc., Ann Arbor, MI; 2Kaiser Optical Systems, SARL, Ecully, FRANCE
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Summary
In the last 15 years Raman spectroscopy has emerged as an important in situ analytical and process control tool. The early years of this period were dominated by improvements in Raman spectrometer components. The later years have seen a significant increase in the type and quantity of published in situ application successes. In this work various examples of the application of Raman spectroscopy for characterization of pharmaceutical components during formulation will be presented.

Code: WOD	Time Slot/Poster Number: 11:00 - 11:20 am	Session: Industrial Applications & Raman Instrumentation
Simultaneous Acquisition of All Four Forms of Circular Polarization ROA using a Modified Scattered Circular Polarization ROA Spectrometer
Honggang Li1; Rina Dukor1; Laurence Nafie2
1Biotools Inc., Jupiter, FL; 2bDepartment of Chemistry, Syracuse University, NY, US
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Summary
A modified BioTools ChiralRAMAN SCP ROA spectrometer will be described that is capable of acquiring simultaneously all four forms of CP ROA. The conversion of this SCP ROA instrument to a complete CP ROA instrument is achieved by first placing a ¼-wave plate into the incident laser beam to create either left or right CP radiation. This is followed by two ½-wave plates that are alternative both, only one, or neither, in the beam. This creates balanced CP modulation of the incident laser radiation.

Code: WOD	Time Slot/Poster Number: 11:20 - 11:40 am	Session: Industrial Applications & Raman Instrumentation
Quantitative Analysis Of Solid Pharmaceutical Formulations Using Transmission Raman Spectroscopy
Magnus Fransson; Jonas Johansson; Anders Sparén; Olof Svensson
AstraZeneca R&D Mölndal, Mölndal, Sweden
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Summary
Raman spectroscopy is in many cases a good alternative for non-destructive quantitative analysis of solid pharmaceutical formulations. The main drawback with Raman for quantitative assessment has been sub-sampling which leads to higher than necessary prediction errors. Transmission Raman spectroscopy has reduced the problem with sub-sampling due to the fact that in transmission mode an entire tablet can be sampled. In this presentation Raman spectroscopy in transmission and backscatter mode will be compared and the advantages of transmission Raman will be shown and discussed. Furthermore, the role of multivariate evaluation and a comparison of different options will be presented.

Code: WOD	Time Slot/Poster Number: 11:40 am - 12:00 pm	Session: Industrial Applications & Raman Instrumentation
Gas-Phase Raman Spectroscopy – A New Tool in the Process Analysis Toolbox
Peter Van Vuuren1; Joseph Slater2; James Tedesco2; Ronald Fairchild2; Ian Lewis2; Phillip Human3
1Process Analytics Consultant, Kingwood, TX; 2Kaiser Optical Systems Inc., Ann Arbor, MI; 3Sasol Synfuels, Secunda, South Africa
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Summary
This paper will describe some key features of gas-phase Raman spectroscopy, its similarities to chromatography and application examples where it has become an alternative replacement technology for on-line process chromatographs in Syngas plants.

Code: WOD	Time Slot/Poster Number: 12:00 - 12:20 pm	Session: Industrial Applications & Raman Instrumentation
Measurement Of Absolute Raman Scattering Cross section and Standoff Raman Detection
Roshan Aggarwal1; Lewis Farrar1; Dennis Polla2
1MIT Lincoln Laboratory, Lexington, MA; 2Defense Advanced Research Projects Agency, Arlington, VA
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Summary
Absolute Raman scattering cross sections (σRS) have been measured using 785- and 1064-nm pump lasers. The spectral response of the Raman spectrometer and the optical system for the collection of the Raman radiation was calibrated using a temperature-controlled, small-cavity blackbody. Values of σRS were determined for 6.5-mm thick single-crystal gallium phosphide (GaP), 0.63-mm thick polycrystalline sulfur, 1-mm thick neat benzene, and 1-mm thick neat benzenethiol. Standoff Raman detection of a 6.5-mm thick GaP sample was made at standoff distances upto 500 m, using a 4-in telescope and 785-nm, 935-mW pump power incident upon the sample.

Code: WOD	Time Slot/Poster Number: 12:20 - 12:40 pm	Session: Industrial Applications & Raman Instrumentation
Improving and Understanding Three Dimensional Spatial Resolution in a Confocal Raman Microscopy and Raman Hyperspectral Imaging I
Eunah Lee1; Bernard Roussel2; Emmanuel Froigneux2; Fran Adar1; Sergey Mamedov1; Andrew Whitley1
1HORIBA Jobin Yvon Inc., Edison, NJ; 2HORIBA Jobin Yvon S.A.S., Villeneuve d'Ascq, France, France
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Summary
Confocal Raman microscopy provides a high spatial resolution because it operates in short wavelength region and utilizes confocal optics. However, the spatial resolution of a confocal Raman microscopy is not well understood, and often confused with the smallest measurable sample size. When performing Raman hyperspectral imaging with a confocal Raman microscope, it is also confused with the smallest distance a mapping stage can step. In this paper, we will provide the theoretical definition, examine the instrumental implementations and present the empirical applications of spatial resolution and related parameters.